Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding

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Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding

Cocrystal formation rates during dry grinding and liquid-assisted grinding were investigated by X-ray powder diffractometry and Raman spectroscopy. Two polymorphic forms of piracetam were used to prepare known piracetam cocrystals as model substances, i.e.,piracetam-citric acid and piracetam-tartaric acid cocrystals. Raman spectroscopy in combination with principal component analysis was used t...

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ژورنال

عنوان ژورنال: Pharmaceutics

سال: 2011

ISSN: 1999-4923

DOI: 10.3390/pharmaceutics3040706